Sr. Scientist Immuno-oncology

Job Description

The Sr. Scientist will support the preclinical development of new immuno-oncology drugs to drive lead selection and pharmaceutical collaborations of the company. The successful candidate will be responsible for the design, execution and interpretation of both in vitro experiments to evaluate drug candidate efficacy and understand the mechanism of action, as well as murine in vivo tumor models. This role will design assays using human and murine primary cells to characterize the MoA of preclinical leads in immuno-oncology models. Hands on experience in in vitro immunological assays (MLR, T cell activation assay, T cell and myeloid differentiation assays…) as well as molecular cloning and syngeneic in vivo tumor models to evaluate antigen specific T cell responses are required; flow-cytometry and human cellular immunology experience is also desired. Aspects of the position also include evaluation of lead compounds in anti-tumor immune responses as well as the effect of various modalities on the tumor microenvironment. The candidate will be required to optimize experimental systems, work independently and direct research associates to ensure timely completion of studies. Strong analytical, written and oral communications skills are required to present experimental findings at internal/external meetings and through written reports.

A successful Sr. Scientist will possess proven skills to optimize experimental systems and solve scientific problems in a dynamic drug discovery environment. Candidates should be highly motivated individuals, strongly laboratory work oriented, with excellent organizational skills. Independent thinking and excellent communications skills are desired.

Essential Duties and Responsibilities

Responsibilities of the position include evaluation of lead compounds in in vitro immunological assays as well as in vivo tumor models, characterization of the anti-tumor immune responses as well as the effect of various modalities on the tumor microenvironment. The candidate will be required to work both independently and in a multidisciplinary team setting under the supervision of the Vice-President of Research and Discovery to ensure timely completion of studies and is expected to present experimental findings at joint project meetings and through written reports.

Desired Qualifications
  • PhD degree in Immunology, Cellular and Molecular Biology, or related field.
  • Minimum of eight years experience in industry life science research.
  • Strong experience in tumor immunology and preclinical drug development.
  • Management experience.
  • Computer proficient (Windows), possess excellent written and oral communication skills.
  • Attention to detail.
  • Experience working in a fast-paced research environment.

 

Email resumes to: resumes@kineta.us


Research Associate Immuno-oncology

Job Description

The Research Associate is expected to effectively support the completion of key studies in the preclinical development of Kineta’s pipeline compounds with a focus on our immuno-oncology compounds. This individual will take a supporting role in studying the in vivo and in vitro pharmacology of the lead drug candidates and support our ongoing research collaborations with pharmaceutical partners. This will include, but not be limited to, drug candidate screening, efficacy studies as well as in vivo and in vitro studies to evaluate drug mechanism of action. On a daily basis, the individual is expected to work independently and be able to engage members from other teams to ensure timely completion and reporting of program objectives. Additionally, the individual will support regular laboratory operations including tissue culture, reagent preparation, equipment maintenance, and organization. They will possess proven skills to adapt and quickly learn a new field of research in a dynamic drug discovery environment including: independent thinking, ability to interpret and present research data and excellent communication skills. As needed, the individual will support other aspects of the preclinical development of these candidate drugs including their formulation, stability, bioanalytical method development and analysis, and functional testing in in vitro and ex vivo models.

Essential Duties and Responsibilities

This candidate will have knowledge and skills to support discovery and preclinical development of small molecules and antibodies being evaluated for immuno-oncology. Work independently and support teams across departments in both program objectives and laboratory management. Ensure experimental optimization, planning, execution, data analysis and interpretation and study report generation.

Desired Qualifications
  • BS Degree in Biosciences and a minimum of 5 years laboratory experience is required.
  • Strong experimental skills with demonstrated ability to plan, optimize and execute experiments.
  • Must be able to work independently and effectively on multiple aspects of the program in a fast-paced environment.
  • Engage literature and knowledge from current scientific advances when planning experiments and interpreting data.
  • Strong experience in tissue culture including primary cells and developing in vitro and ex vivo immuno-assays is required.
  • Strong experience in molecular biology including cloning, new crispr technology, protein expression and immunoassays.
  • Experience supporting in vivo models including tumor biology is desired.
  • Must support the management of laboratory operations including ordering and receiving incoming items, waste disposal, regular cleaning and maintenance of the laboratory space, regular and as needed equipment maintenance, equipment alarm response, monthly lab safety audits for the EH+S.
  • Management of daily and weekly laboratory maintenance tasks and lab organization.
  • Must work with peers, operations personnel, and outside vendors to maintain and improve lab operations and troubleshoot supply and equipment issues.
  • Experience working in a fast-paced research environment

 

Email resumes to: resumes@kineta.us


Research Assistant

Job Description

Kineta is seeking a motivated individual to provide animal husbandry and laboratory operations support. Animal husbandry responsibilities include general care, facility maintenance, regular health checks and maintenance of health and integrity of the rodent colony. Ability to work in a highly regulated environment following standard operating procedures (SOPs) and federal regulations is required. The successful candidate will be expected to work in collaboration with the attending veterinarian to develop procedures and resolve any health-related issues. Additionally, this position will perform general laboratory support activities including purchasing, management of lab supply inventory and stocking, glassware, and reagent preparation. The position will require working closely with research scientists and provide technical support as needed. A high level of organization is required with excellent written and oral communication skills.

The successful candidate will have relevant experience and the desire to learn laboratory procedures in a drug development environment. Kineta is seeking a highly motivated individual with excellent organizational skills and the ability to work both independently and as the member of a team in a fast-paced start-up environment. Careful attention to detail and excellent communications skills are required. The ability to work full time is preferred; however, part-time will be considered for the right candidate.

Desired Qualifications
  • B.S. or B.A. degree or 2 years relevant laboratory experience.
  • The ability to work with laboratory animals is required, previous experience working in a regulated animal health care facility is desired.
  • Must be computer proficient (Windows), possess good written and oral communication skills, show attention to detail, and have experience working in a fast-paced research environment.

 

Email resumes to: resumes@kineta.us